Intrinsic functional architecture in the anaesthetized monkey brain  

Oleh:

Vincent, J.L. ; Patel, G.H. ; Fox, M.D ; Snyder, A.Z. ; Baker, J.T ; Essen, D.C. van ; Zempel, J.M. ; Snyder, L.H. ; Corbetta, M ; Raichle, M.E.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: NATURE (keterangan: ada di Proquest) vol. 447 no. 7140 (May 2007), page 83.

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Perpustakaan FK Nomor Panggil: N01.K.2007.05 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The traditional approach to studying brain function is to measure physiological responses to controlled sensory, motor and cognitive paradigms. However, most of the brain's energy consumption \I, devoted to ongoing metabolic activity not dearly associated with my particular stimulus or behaviour'. Functional magnetic resIInance imaging studies in humans aimed at understanding this ~g activity have shown that spontaneous fluctuations of the D1ood-oxygen-Ievel-dependent signal occur continuously in the It'Stjng state. In humans, these fluctuations are temporally coherent within widely distributed cortical systems that recapitulate the functional architecture of responses evoked by experimentally administered tasks2-6. Here, we show that the same phenomenon is present in anaesthetized monkeys even at anaesthetic levels I known to induce profound loss of consciousness. We specifically demonstrate coherent spontaneous fluctuations within three well known systems (oculomotor, somatomotor and visual) and the 'default' system, a set of brain regions thought by some to support uniquely human capabilities. Our results indicate that coherent system fluctuations probably reflect an evolutionarily conserved aspect of brain functional organization that transcends levels of consciousness.

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