Stability and flexibility of epigenetic gene regulation in mammalian development  

Oleh:

Reik, W.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: NATURE (keterangan: ada di Proquest) vol. 447 no. 7143 (May 2007), page 425.

Ketersediaan

Perpustakaan FK Nomor Panggil: N01.K.2007.05 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Development is inherently epigenetic. In the absence of changes to the DNA sequence, blastocyst cells alter their gene-expression programmes as they differentiate into the many cell types that constitute an organism. Gene-expression programmes can be 'locked in' by epigenetic marks such as DNA methylation; however, during development, there is also a requirement for flexibility and reversibility. And there is great interest in how DNA methylation can be removed.

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