Effects of phytosterols in diacylglycerol as part of diet therapy on hyperlipidemia in children  

Oleh:

Matsuyama, Takeshi ; Shoji, Kentaro ; Takase, Hideto ; Kamimaki, Isamu ; Tanaka, Yuriko ; Otsuka, Atsuka ; Watanabe, Hiroyuki ; Hase, Tadashi ; Tokimitsu, Ichiro

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Asia Pacific Journal of Clinical Nutrition (keterangan: ada di Proquest) vol. 16 no. 01 (2007), page 40.
Topik: diacylglycerol; phytosterols; cholesterol; lipoprotein(a); children

Ketersediaan

Perpustakaan FK Nomor Panggil: A27.K.2007.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Background: The incidence of hyperlipidemia in children is increasing in Japan , but drug therapy for such children is limited. The ingestion of 4% phytosterols-containing diacylglycerol (PS/DAG) decreases serum total cholesterol and low density lipoprotein cholesterol (LDL-C) concentrations in adults. In the present study, we examined the effect of PS/DAG as part of a diet therapy in pediatric patients with hyperlipidemia. Methods: Pediatric patients with hyperlipidemia with = 5.18mmol/L (200 mg/dL) serum total cholesterol and/or =1.70mmol/L (150 mg/dL) triglycerides (N = 22) ingested bread containing PS/DAG (total daily intake, 10g ) for 6 months. Blood chemistry was examined prior to and 2, 4, 6 months after the initiation of ingestion, and 4 months after the ingestion period. Results: No significant differences in energy intake or cholesterol intake during the study period were found. After 4 months of ingestion of PS/DAG, LDL-C, lipoprotein(a) [Lp(a)], free fatty acids and total ketone bodies decreased significantly. In seven patients with familial hypercholesterolemia, total cholesterol and remnant-like lipoprotein particles (RLP)–cholesterol also significantly decreased in addition to LDL-C and Lp(a). Conclusions: PS/DAG improves serum lipid metabolism in pediatric patients with hyperlipidemia for whom drug therapy is limited, suggesting that PS/DAG may reduce the risk of developing various diseases induced by hyperlipidemia.

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