Obstetric Complications in Patients With Hereditary Thrombophilia Identified Using the LCx Microparticle Enzyme Immunoassay: A Controlled Study of 5,000 Patients  

Oleh:

Kocher, Olivier ; Cirovic, Christine ; Malynn, Elizabeth ; Rowland, Charles M. ; Bare, Lance A. ; Young, Bradford A. ; Laffler, Thomas G. ; Huff, Jeffrey B. ; Kruskall, Margot S. ; Wong, Geoffrey ; Bauer, Kenneth A.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: American journal of Clinical Pathology vol. 127 no. 1 (Jan. 2007), page 68 - 75.
Topik: Genetic thrombophilia; Factor V Leiden; Prothrombin mutation; Pregnancy; Complications

Ketersediaan

Perpustakaan FK Nomor Panggil: A08.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Factor V Leiden (FVL) and prothrombin (PT) G20210A mutations are associated with increased risk of deep venous thrombosis, pulmonary embolism, and obstetric complications. The development of inexpensive and reliable screening methods will assist in defining subpopulations of patients at risk who should undergo testing. We used a method, developed by Abbott Laboratories (Abbott Park, IL), to study 5,000 pregnant women and evaluated the association of obstetric complications with the presence of the FVL and PT G20210A mutations. We found a statistically significant association between FVL and stillbirth. There were also trends toward an association between FVL and placental abruption and between PT G20210A and intrauterine growth retardation. In addition, an association may exist between PT G20210A and preterm delivery for white women. All other parameters studied, including miscarriage and preeclampsia, did not show a statistically significant association with FVL or PT G20210A. These results confirm the association between genetic thrombophilia and selected obstetric complications.

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