PERUBAHAN RESPONS RESEPTOR ADRENERGIK-B DAN MUSKARINIK DI OTOT POLOS SALURAN NAFAS TIKUS WISTAR PADA PROSES PENUAAN. ALTERATION OF THE B-ADRENERGIC AND MUSCARINIC RECEPTORS RESPONSIVENESS IN AIRWAY SMOOTH MUSCLE OF WISTAR RAT DURING AGING  

Oleh:

Karyono, Setyawati Soeharto

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: Jurnal Kedokteran Brawijaya vol. 22 no. 03 (Dec. 2006), page 142-150.
Topik: Aging; b-adrenergic Receptors; Muscarinic Receptors; Airways

Ketersediaan

Perpustakaan FK Nomor Panggil: J34.K.2004-2006.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Aging process is a unique and complex process which could not be prevented. Many physiologic changes could be seen for adaptation during aging process. These changes influence pharmacodynamic and pharmacokinetic of drug and cause alteration of drug effect. Pharmacodynamic changes are caused by alteration of drug receptor The objective of this study was to evaluate the influence of aging on b-adrenergic and muscarinic receptors function in rat airway smooth muscle. Isolated tracheal ring preparation and lung strip were used to examine relaxation response to isoprenaline (b-adrenergic agonist) and contraction response to metacholine (muscarinic agonist). Tracheal ring preparations and lung strip were taken from young (4-5 weeks), adult (4-6 months) and old (24-26 months) wistar rats. The results showed that the b-adrenergic receptor response significanily decreased (p<0,05) in tracheal ring and lung strip from aged rat as compared to young and adult rat.. This study has also demonsfrated that muscarinic receptor responsiveness of lung strip significantly increased (p<0,05) in aged rat as compared to young and adult rat. These results suggested that the alteration of b-adrenergic and muscarinic receptor function in airway smooth muscle caused by homolog and heterolog receptor regulation during aging. Further studies is needed to discover the definite mechanism of receptor regulation in aging.

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