PREDIKTOR ASMA PADA USIA 7 TAHUN SETELAH MENDERITA BRONKIOLITIS AKUT KARENA RESPIRATORY SYNCYTIAL VIRUS: SUATU STUDI PROSPEKTIF. PREDICTORS OF ASTHMA AT AGE 7 AFTER RESPIRATORY SYNCYTIAL VIRUS BRONCHIOLITIS: A PROSPECTIVE STUDY  

Oleh:

Kusuma, HMS. Chandra

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: Jurnal Kedokteran Brawijaya vol. 22 no. 03 (Dec. 2006), page 127-130.
Topik: Respiratory Syncytial Virus (RSV); Bronchiolitis; Asthma; lL-4; IFN-g Ratio; Wheezing Episodes; FEV1.

Ketersediaan

Perpustakaan FK Nomor Panggil: J34.K.2004-2006.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Infants are at increased risk of developing asthma after RSV (Respiratory Syncytial Virus) acute bronchiolitis. The hypothesis that cytokine production is related to the development of asthma after RSV bronchiolitis. The diagnosis of RSV bronchiolitis was verified using the Abbott test pack RSV, a rapid enzyme immuno assay for direct detection of viral antigen in nasophaiyngeai secretion. Changes in FEVI (Forced Expiratory Volume in I second) were determined using spirometri, lL-4 and IFN-g levels were determined using the enzyme-linked immunosorbant assay (ELISA) method. In this study, 62 children hospitalized for RSV bronchiolitis were followed prospectively, 55 (88.7%) children completed the study and 41 children (74.5%) had asthma at 7 years of age. RSV bronchiolitis children were more frequent among boys (boy/girl ratio: 2). Episodes of wheezing more than 8 had specifity and sensitivity of 100% respectivelly, might be the very useful predictor for asthma. The cut off level over 40.84 pg/mi for lL-4, below 14.12 pg/ ml for 1FN-g, lL-4 / IFN-g ratio over 3 and episodes of wheezing over 8 may be used to predict asthma after RCV bronchioiitis. Infants with asthma had higher IL-4 levels (p = 0.004) lower levels of 1FN-g (p = 0.599), higer IL-4 / IFNg ratio (p = 0.000) and higer episodes of wheezing (p = 0.000) when compared with those who had no asthma. In conclusions, the higher levels of 1L-4, higher IL-4 /IFN-g ratio, lower IFN-g levels at the time of RSV bronchiolitis and higher episodes of wheezing may be used to predict asthma after RSV bronchiolitis later in life.

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