EFEK ANTI BAKTERI EKSTRAK KULIT BUAH DELIMA (PUNICA GRANATUM) TERHADAP SHIGELLA DYSENTRIAE SECARA iN VITRO. ANTIBACTERIAL EFFECT OF POMEGRANATE’S (PUNICA GRANATIUM) RIND EXTRACT AGAINST SHIGELLA DYSENTRIAE IN VITRO  

Oleh:

Prihantoro, Teguh ; Indra, Rasjad ; Sumarno

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: Jurnal Kedokteran Brawijaya vol. 22 no. 03 (Dec. 2006), page 101-106.
Topik: Shigella Dysentriae; Pomegranate’s Rind Extract; Antibacterial Activity

Ketersediaan

Perpustakaan FK Nomor Panggil: J34.K.2004-2006.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Shigella dysentriae is the most common organisms which causes bacillaiy dysentety in developing countries with mortality. Pomegranates (Punica granatum) have been used since a long time ago in folk medicine for several The antibacterial activity was linked to the presence of major phytocompounds like flavonoids, triterpenes, and ellagitannin. The aim of this experimental study was tO evaluate the antibacterial effect of Pomegranate’s (Punica Granatum) rind extract against Shigella dysentriae and to determine the relationship between concentrations of Pomegranate’s rind extract with the growth of Shigella dysentriae in vitro. Antimicrobial effect was determined by tube dilution method. This consists of determination of Minimum Inhibitory Concentrations (MICs), and Minimum Bactericidal Concentrations (MBCs). The concentrations of Pomegranate’s (Punica Granatum) rind extract were 0.8%, 1%, 1.2%, 1.4%, 1.6%, and 1.8%. At low extract concentration (0.8%) bacterial growth was delayed, while at higher extract concentration (1.8%) bacterial growth was elimanited (ANOVA, p = 0.000, Regression R = -0.90 1). The Minimum lnhibitoiy Concentrations (MICs) value could not be obtained, while the Minimum Bactericidal Concentrations (MBCs) value on 1.8%. The conclusion of this experimental study is that pomegranate’s rind extract has antibacterial effect against Shigella dysentriae.

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