KEGAGALAN KEHAMILAN AKIBAT INFEKSI Toxoplasma gondii GALUR RH DIPICU OLEH OVERPRODUKSI INTERFERON GAMMA (IFNy). PREGNANCY FAILURE IN RH STRAIN OF Toxoplasma gondii INFECTION IS INDUCED BY OVERPRODUCTION OF INTERFERON GAMMA (IFNy)  

Oleh:

Sardjono, Teguh Wahju

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: Jurnal Kedokteran Brawijaya vol. 21 no. 03 +suplemen (Dec. 2005), page 133-136.
Topik: Toxoplasmosis; IFNy-overproduction; Pregnancy Failure
Fulltext: 133-136 - Bernard.pdf (131.09KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: J34.K.2004-2006.01 Non-tandon: 2 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

It has been already known that transplacental infiltration of parasites occurred during Toxoplasma infection in pregnancy; but pregnancy failures may due to some other previous mechanisms. Eighty BALBIc female mice were monogamously mated than devided into three pairs of study groups and a pair of control group. On Day 9th post mating, three pairs of study groups were intra-peritoneally infected by 10, 50 and 100 tachyzoites of RH strain Toxoplasma gondi,, and the ~ontrol groups were injected by PBS. Effect of treatment on the plasma level of IFN7 (ELISA) and number of litters were evaluated on the day I2thand day 15h~I6th, represented second and third period of pregnancy. ANOVA and Path Analysis showed that duration of infection and the increase of plasma lFNy level decreased number of litters with coefficients of path of (-0,269; p=0,005) and (-0,377; p= 0,002) respectively. Decreasing number of litters was due to IFN1 overproduction, as response against RH strain of Toxoplasma gondii infection. This study showed that pregnancy failure in Toxoplasma infection is more due to indirect immuno-biochemical aspects rather than direct parasitological aspect. More studies to explain the basic molecular and immunological mechanisms of pregnancy failure in toxoplasmosis are still needed.

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