HIPERHOMOSISTEINEMIA SEBAGAI RISIKO PENYAKIT JANTUNG KORONER. HYPERHOMOCYSTEINEMIA AS A RISK FOR CORONARY HEARTH DISEASE  

Oleh:

Irawan, Bambang ; Sja’bani, Mochammad

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: Jurnal Kedokteran Brawijaya vol. 21 no. 03 +suplemen (Dec. 2005), page 103-109.
Topik: Honiocysteine - Risk Factor - Cardiovascular Disease - Case-Control
Fulltext: 103-109 - Bernard.pdf (146.73KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: J34.K.2004-2006.01 Non-tandon: 2 (dapat dipinjam: 0) Tandon: tidak ada

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The elevation of total plasma homocysteine is associated with increase of risk for cardiovascular disease, cerebrovascular disease, and atherothrombosis in peripheral arteries. Several prospective and retrospective studies had conformed the positive association between hyperhomocysteinemia and risk for cardiovascular disease. However, it. whether hyperhomocysteinemia is an independent risk factor for cardiovascular disease associated with the others risk factors still become a question. The aim of this study was to identify the association between hyperhomocysteinemia and increased risk for cardiovascular disease. A matched case-control study based on 50 consecutWe adult patients aged more than 18 years old who admitted in Dr. Sardjito General Hospital by first acute coronaiy syndrome. Fifty comparison control subjects were randomly selected age and gender group-matched patients admitted caused by conditions other than cardiovascular disease to the same hospital. Each case was enrolled, and comparison subject was randomly selected. Fasting blood samples for homocysteine were obtained from both groups. Chi square test, McNemar chi square test, and independent t test had been used in univariate analysis. Confounding factors had been analysed using stratification technic (Mantel-Haenszel test) and logistic regression multivariate analysis. Mean age was 61,46 ± 10,62 (case) and 60,88 ± 10,72 (con trol) years; 82 % were male (cases and controls). Mean fasting homocysteine levels were significantly higher in cases than in controls (24,82 ± 12,69 pmollL vs 14,74 ± 5,96 pmo!/L, 95% Cl: 6,23 - 13,93). Compared with the lowest homocysteine tertile, the highest tertile was significantly had higher odds ratio associated with an OR 5,48 (95% Cl: 2,12-13,12; p= 0,019) for cardiovascular disease. Using McNemar chi square test, the odds ratio was 4,80 (95% Cl: 2,11-10,85; p = 0,001). Using a logistic regression, the odds ratio was 5,67 (95% Cl: 3,16 - 17,61; p < 0,01). Hyperhomocysteinemia is an independent risk factor for coronary hearth disease.

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