Effect of high-dose iron supplements on fractional zinc absorption and status in pregnant women  

Oleh:

Harvey, Linda J. ; Dainty, Jack R. ; Hollands, Wendy J ; Bull, Victoria J. ; Hoogewerff, Jurian A ; Foxall, Robert J. ; McAnena, Liadhan ; Strain, J.J. ; Fairweather-Tait, Susan J.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 85 no. 01 (Jan. 2007), page 131.
Topik: Pregnancy • iron supplements • stable isotopes • zinc • women • iron status • absorption

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2007.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

1 From the Institute of Food Research, Norwich Research Park, Colney, Norwich, United Kingdom (LJH, JRD, WJH, VJB, JAH, RJF, and SJF-T), and the University of Ulster, Coleraine, Northern Ireland (LM and JJS). Background: Women have an increased risk of iron deficiency during pregnancy because of the demands of the developing fetus. Iron supplements are commonly advocated as a prophylactic treatment and are generally taken with meals to reduce side effects, but iron can interfere with the absorption of zinc. Objective: The aim was to determine the effect of consuming an iron supplement (100 mg Fe/d as ferrous gluconate) with meals from 16 wk gestation to term on zinc status and absorption. Design: Stable-isotope techniques were used to measure zinc status (exchangeable zinc pool, EZP) and fractional zinc absorption (FZA) in early and late pregnancy from a meal consumed at a different time from that of iron supplement or placebo consumption in 6 women given iron supplements and 7 given a placebo. Results: FZA increased during pregnancy, independent of iron supplementation. FZA was significantly higher (P < 0.001) at week 34 than at weeks 16 and 24, and urinary zinc excretion was higher at week 34 than at week 16 (P = 0.02). The size of the EZP remained unchanged throughout pregnancy and was unaffected by iron supplementation. The iron status of iron-supplemented women was higher than that of the placebo group. Conclusions: In iron-replete pregnant women who consumed a Western diet, no detectable adverse effects on zinc metabolism were observed after ingestion of 100 mg Fe/d. An increase in the efficiency of zinc absorption was observed during late pregnancy.

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