Peningkatan Potensi Sediaan Metil Prednisolon Palmitat sctelah Inkorporasi Dengan Laposom, Suatu Studi Efek Antiplamasi pada Kultur Splenosit Mencit  

Oleh:

Arozal, Wawaimuli ; Suyatna, Fransiscus D. ; Purwaningsih, Ernie H. ; Dewoto, Hedi R.

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Makara Seri Kesehatan vol. 9 no. 2 (2005), page 49-56.
Topik: Antiinflammation; Gamma Interferon; Liposome-Methyiprednisolone Palmitate

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: MM75.1 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The Improving of Methyiprednisolone Palmitate Potency After Incorporated With Liposome. An Antiinflammation Study In Culture Of Mice’s Splenocytes. Glucocorticoid has been used as an antiinflammatory and immuno-suppresive drug. Longterm utilisation at high dose of glucocorticoid is associated with serious side effects. In recent years, many attempts have been performed in searching the appropiate vehicles to deliver the drug directly into the target organ or the receptor. By incorporating the drug into its vehicle such as liposome, the systemic side effect can be minimized. Purwaningsih et al has successfully synthetized a novel preparation of liposome methyiprednisolone palmitate (L-MPLP). The aim of the study was to learn the pharmacological effect of L-MPLP, especially on antiinfiammatory effect of this novel preparation, compared with the standard methylprednisolone (MPL). The parameter was the potency of L-MPLP in reducing gamma-interferon production in T-lymphocyte culture after stimulation with concanavalin A in vitro as well as in vivo. Gamma-interferon was assayed by ELISA method. The reduction of gamma interferon, in vivo, after the administration of L-MPLP at the dose of 2,8 and 16 mg/kgBW respectively, showed significant difference than a control grou1, while MPL did not. The addition of both L-MPLP and MPL in in vitro culture at the concentration of 5.lO~, 5.10 and 5.10’ mM have proved to suppress the gamma-interferon production, where the suppression of L-MPLP was more effective than MPL, significantly.

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