Growth and Neuroendocrine Dysfunction Following Therapy for Childhood Cancer  

Oleh:

Sklar, Charles A.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Pediatric Clinics of North America vol. 44 no. 02 (Apr. 1997), page 489.

Ketersediaan

Perpustakaan FK Nomor Panggil: P13.K.1997.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Impaired linear growth and short adult stature are established complications of the therapy for childhood cancers and can be caused by various factors, both endocrine and nonendocrine. The major risk factors for decreased growth include younger age at treatment, female sex, and irradiation of the head or spine. Growth hormone deficiency and early sexual maturation can be observed following hypothalamic-pituitary doses of radiation as low as 18 Gy; higher doses (> 35—40 Gy) are associated with deficiency of LH/FSH, TSH, and ACTH as well as hyperprolactinemia.

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