Genetic Predisposition to Cancer and Familial Cancer Syndromes  

Oleh:

Quesnel, Susan ; Malkin, David

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Pediatric Clinics of North America vol. 44 no. 04 (Aug. 1997), page 791.

Ketersediaan

Perpustakaan FK Nomor Panggil: P13.K.1997.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Approximately 10% to 15% of childhood cancers are hereditary or familial in nature. For several genetic disorders, the development of cancer is a secondary manifestation of the clinical phenotype, whereas cancer predisposition syndromes are generally recognized by the manifestation of characteristic malignancies. The study of pediatric cancer and rare hereditary cancer syndromes and associations has led to the identification of numerous cancer genes that are known to play critical roles in both normal and abnormal celluler growth, differentiation and proliferation. The potential to identify such genetic markers of cancer predisposition poses difficult social, legal and ethical questions in their application to clinical practice.

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