CMT-Type B-Lactamase TEM-125, an Emerging Problem for Extended-Spectrum B-Lactamase Detection  

Oleh:

[s.n]

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Antimicrobial Agents and Chemotherapy vol. 50 no. 07 (Jul. 2006), page 2403.
Topik: B-Lactamase

Ketersediaan

Perpustakaan FK Nomor Panggil: A21.K, A21.K.2006.03 Non-tandon: 3 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

The clinical strain E.Coli TO799 was resistant to penicilin-clavulanate combinations and ceftazidime and was not reproducibly detected as an extended-spectrum B-Lactamase (ESBL) according to the standards of the Clinical Laboratory Standards Institute (CLSI; formerly NCCLS) and the national guidelines of the French Society for Microbiology ( Comite de Antibigramme de la Societe Francaise de Microbiologie). A novel B-Lactamase, designated TEM-125, was resposible for this phenotype. TEM-125 harbors a complex association of mutations previously described in the ESBL TEM-12 and in the inhibitor-resistant B-Lactamase TEM-39. TEM-125 is the first complex mutant TEM to present hydrolytic activity against ceftazidime together with a high level of resistance to clavulanate. The discovery of such an ESBL, which is difficult to detect by the usual ESBL detection methods, confirms the emergence of a complex mutant TEM subgroup and highlights the need to evaluate detection methods so as to avoid possible therapeutic failures.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali