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In Vivo Fluconazole Pharmacodynamics and Resistance Development in a Previously Susceptible Candida albicans Population Examined by Microbiologic and Transcriptional Profiling
Oleh:
[s.n]
Jenis:
Article from Journal - ilmiah internasional
Dalam koleksi:
Antimicrobial Agents and Chemotherapy vol. 50 no. 07 (Jul. 2006)
,
page 2384.
Topik:
Fluconazole
;
Candida albicans
Ketersediaan
Perpustakaan FK
Nomor Panggil:
A21.K, A21.K.2006.03
Non-tandon:
3 (dapat dipinjam: 0)
Tandon:
tidak ada
Lihat Detail Induk
Isi artikel
Antimicrobial drug resistance can limit the ability to effectively treat patients. Numerous factors have been proposed to impact the development of antimicrobial resistance, including those specific to the drug and the dosing regimen.The field of investigation that examines the relationship between dosing regimen and outcome is termed antimicrobial pharmacokinetics and pharmacodynamics. Global transcriptional profiling of cell populations during the progressive emergence of a resistance phenotype provides insight into the mechanisms underlying this complex physiologic process.
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