Absorption, Metabolism, and Excretion of Viramidine in Human  

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Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Antimicrobial Agents and Chemotherapy vol. 50 no. 07 (Jul. 2006), page 2368.
Topik: Viramidine in Human

Ketersediaan

Perpustakaan FK Nomor Panggil: A21.K, A21.K.2006.03 Non-tandon: 3 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Absorption, metabolism, and excretion of viramidine, a prodrug of ribavirin, were studied in humans following a single oral dose (600 mg). Viramidine was rapidly absorbed, with a time to maximum concentration of the drug in plasma of 1.5 h. The metabolic profile in urine (0 to 24 h) indicated that viramidine was excreted primarily as triazole carboxamide (TCONH2), triazole carboxylic acid nucleoside (TCOOH), and ribavirin with a small amount of unchanged viramidene, which each accounted for 64.1%, 17%, 15.7%, and 3.2% of urinary radioactivity, respectively. The amounts of unchanged viramidine(3.4% of dose) and ribavirin (10% of dose) in urine were small after oral administration of viramidine.

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