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BukuPhysiologic Factors Contributing to a Transition in Oral Immunity among Mechanically Ventilated Adults
Bibliografi
Author: O'Neal, Pamela V. ; Brown M.M., Nicole (Co-Author); Munro, Cindy (Co-Author)
Topik: Ventilator-associated pneumonia; nosocomial pneumonia; immune system; oral immunity; oral secretions; mechanical ventilation
Bahasa: (EN )    
Penerbit: SAGE Publications     Tempat Terbit: London    Tahun Terbit: 2002    
Jenis: Article - untuk jurnal ilmiah
Fulltext: 132BRN33.pdf (43.0KB; 2 download)
Abstract
Ventilator-associated pneumonia (VAP), a specific type of nosocomial pneumonia, occurs in approximately 21% of patients in intensive care, and the mortality can be as high as 71%. VAP causes considerable mortality and morbidity, and it exponentially increases health care costs. The incidence of VAP is associated with or opharyngeal colonization of gram-negative bacteria. Within 48 h of hospital admission, the composition of the oropharyngeal flora of critically ill patients undergoes a change from the usual gram-positive streptococci and dental pathogens to a predominant gram-negative flora that includes more virulent organisms, which predispose patients to VAP. Identification and understanding of this oral transition from gram-positive to predominantly gram-negative flora may assist health care professionals in differentiating among oral immune markers that suggest compromised immunity. The purpose of this article is to provide a review of the literature that promotes an understanding of current knowledge about the transition of oral immunity in mechanically ventilated patients.
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