Efek Perlindungan Sel Endothel oleh Ekstrak Air Bawang Putih (Allium sativum Linn.) pada Hyperkolesterolemia  

Oleh:

Sugihartuti, Rahmi ; Maslachah, Lilik

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: Jurnal Penelitian Medika Eksakta vol. 04 no. 01 (Apr. 2003), page 44-50.
Topik: Endothelial Cell; Garlic Extract; Hypercholesterolemia
Fulltext: Rahmi Sugihartuti.pdf (123.15KB)

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Perpustakaan PKPM Nomor Panggil: J101 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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The aim of this study was to prove that aqueous extract of garlic can prevent endothelial cell damage on hypercholesterolemia. This study used Completely Randomised Design. Thirty five male rabbits (1,5 – 2 kg BW) were used in the experiment. Rabbits were divided into five groups of seven each and were treated as follows: Group A AS negative control were given aquadest 5 ml/kg BW/day for 4 weeks; Group B AS positive control were given aquadest 5 ml/kg BW/day + cholesterol 0,2 g /kg BW/day for 4 weeks; Group C AS positive control were given cholesterol 0,2 g /kg BW/day + aqueous extract of garlic 25%, 5 ml/kg BW/day for 4 weeks. Group D AS were given cholesterol 0,2 g /kg BW/day + aqueous extract of garlic 50%, 5 ml/kg BW/day for 4 weeks. Group E AS were given cholesterol 0,2 g/kg BW/day + aqueous extract of garlic 75%, 5 ml/kg BW/day for 4 weeks. The result showed that aqueous extract of garlic decresed circulating endhotel (p<0,1), but not MDA (p>0,1). Increasing dose of aqueous extract of garlic could not decrease (p>0,1) circulating endothel and MDA. It is recommended that administration aqueous extract of garlic over 4 weeks.

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