In Vivo Modeling of Interstitial Pressure in The Brain Under Surgical Load Using Finite Elements  

Oleh:

Miga, Michael I. ; Roberts, David W. ; Hartov, Alex ; Kennedy, Francis E. ; Hoopes, Jack P. ; Paulsen, Keith D.

Jenis: Article from Bulletin/Magazine
Dalam koleksi: Journal of Biomechanical Engineering vol. 122 no. 4 (2000), page 354-363.
Topik: in vivo models; vivo modeling; interstitial pressure; brain; surgical load; finite element

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: JJ52.2 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Current brain deformation models have predominantly reflected solid constitutive relationships generated from empirical ex vivo data and have largely overlooked interstitial hydrodynamic effects. In the context of a technique to update images intraoperatively for image - guided neuronavigation, we have developed and quantified the deformation characteristics of a three - dimensional porous media finite element model of brain deformation in vivo. Results have demonstrated at least 75 – 85 percent predictive capability, but have also indicated that interstitial hydrodynamics are important. In this paper we investigate interstitial pressure transient behaviour in brain tissue when subjected to an acute surgical load consistent with neurosurgical events. Data are presented from three in vivo porcine experiments where subsurface tissue deformation and interhemispheric pressure gradients were measured under conditions of an applied mechanical deformation and then compared to calculations with our three - dimensional brain model. Results demonstrate that porous - media consolidation captures the hydraulic behaviour of brain tissue subjected to comparable surgical loads and that the experimental protocol causes minimal trauma to porcine brain tissue. Working values for hydraulic conductivity of white and gray matter are also reported and an assessment of transient pressure gradient effects with respect to deformation is provided.

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