Profil Imunohistokimia Superoksida Dismutase (SOD) pada Jaringan Hati Tikus dengan Kondisi Hiperkolesterolemia  

Oleh:

Wresdiyati, Tutik ; Astawan, Made ; Hastanti, Lusia Yuni

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Hayati Journal of Biosciences vol. 13 no. 3 (Sep. 2006), page 85-89.
Topik: superoxide dismutase; Superoxide Dismutase (SOD); Hypercholesterolemia; Liver; Rat
Fulltext: 78.pdf (117.88KB)

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: HH13.8 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

This study was conducted to observe intracellular antioxidant cooper, zinc superoxide dismutas (CU, Zn-SOD) in liver tissue of rats under hypercholesterolemic condition by using immunohistochemical technique. A total of twenty male wistar rates were used for this study. Those rats were divided into two groups: i. control group and ii. hypercholesterolemic group, which were fed died containing 1% cholesterol for eight weeks. Rat livers were taken at the end of treatment, and processed by using paraffin embedding standard method. The tissue were stained immunohistochemically to Cu, Zn-SOD, Observation of CU, Zn-SOD content in the tissue was performed qualitatively in the cytoplasm and quantitatively in the nucleus of hepatocytes based on colour intensity of enzyme reaction product. The profile of antioxidant Cu, Zn-SOD decreased (P < 0,05) in the hypercholesterolemic group compared to the control group.

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