Is There a Neuropathology of Schizophrenia? Recent Findings Converge on Altered Thalamic-Prefrontal Cortical Connectivity  

Oleh:

Lewis, David A.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Neuroscientist vol. 6 no. 3 (Jun. 2000), page 208–218.
Topik: Schizophrenia; Prefrontal cortex; Mediodorsal thalamus; Dopamine; GABA; Pyramidal neuron
Fulltext: 208TN63.pdf (217.65KB)

Isi artikel

Schizophrenia is a serious and chronic brain disorder whose underlying neuropathology has proven difficult to identify. This article reviews the current status of neuropathological studies in terms of how they inform the diagnosis, pathogenesis, pathophysiology, and mechanisms of treatment of schizophrenia. Although additional studies are required, substantial data converge on the hypothesis that the pathophysiology of schizophrenia is associated with alterations in thalamic-prefrontal cortical connectivity.

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