Na+ Signals at Central Synapses  

Oleh:

Rose, C.R.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Neuroscientist vol. 8 no. 6 (Des. 2002), page 532–539.
Topik: Sodium; Synapse; Spine; Dendrite; SBFI
Fulltext: 532TN86.pdf (305.66KB)

Isi artikel

A basic characteristic of animal cells is the maintenance of a steep inwardly directed electrochemical gradient for sodium ions. In vertebrate neurons, this Na+ gradient energizes intracellular ion regulation and enables influx of Na+ during action potentials and excitatory postsynaptic currents. Several studies suggested that Na+ ions could also play a role in activity-dependent synaptic plasticity. This review focuses on recent studies that demonstrated the presence of substantial intracellular Na+ transients during action potential firing or excitatory synaptic transmission in postsynaptic dendrites and dendritic spines. The large amplitudes of these activity-induced Na+ transients suggest that this signal will significantly alter electrical and biochemical properties of spines and dendrites and might influence the properties of synaptic transmission.

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