Stem Cells and Regeneration in the Retina: What Fish Have Taught Us about Neurogenesis  

Oleh:

Easter, Stephen S., (Jr.) ; Hitchcock, Peter F.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Neuroscientist vol. 6 no. 6 (Des. 2000), page 454–464.
Topik: Stem cell; Retina; Neurogenesis; Regeneration; Repair
Fulltext: 454TN66.pdf (176.61KB)

Isi artikel

Many species of fish grow for much of their lifetimes and add neurons to the CNS continuously. The retina has proved to be a convenient model in which to study neurogenesis, both the normal variety associated with growth and regeneration in response to a lesion. Initial neurogenesis in the embryonic eye cup begins in a tiny cluster of neuroepithelial cells that steadily enlarges to produce a central disk of neurons. Subsequent growth occurs mainly at the edge of this disk, in the circumferential germinal zone, where the retina adds annuli of new neurons of all varieties except the rod photoreceptors. A few proliferative cells persist to adulthood in central retina and normally produce only rods, but when the retina is damaged, these cells contribute to the production of new neurons of diverse classes. Recent work has revealed two additional populations of dividing cells in central retina; they normally proliferate so slowly that special methods are required to reveal them. We suggest that the three proliferative cell types are related through lineage in a model similar to those described for hematopoiesis. The persistent neurogenesis of fish retina seems to resemble qualitatively the neurogenesis of the mammalian brain, but quantitatively the neurogenesis is much more vigorous in the fish.

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