Serotonin 2C Receptors: Suicide, Serotonin, and Runaway RNA Editing  

Oleh:

Schmauss, Claudia

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Neuroscientist vol. 9 no. 4 (Agu. 2003), page 237–242.
Topik: Serotonin; RNA editing; Serotonin 2C receptor; Prefrontal cortex; Major depression; Schizophrenia
Fulltext: 237TN94.pdf (84.12KB)

Isi artikel

Transcripts of the gene encoding the serotonin 2C receptor are modified by RNA editing, a posttranscriptional process that converts adenosines to inosines. This editing changes up to three genomically encoded amino acids located in the second intracellular loop of the G-protein-coupled receptor. Compared with nonedited receptors, extensively edited receptor isoforms activate G protein less efficiently. Studies on mice revealed that 5-HT2C pre-mRNA editing is regulated in a serotonin-dependent manner, and postmortem studies on brain tissues of patients with schizophrenia and major depression found distinct sitespecific alterations of this editing in the prefrontal cortex, a brain region expressing a large number of differently edited 5-HT2C mRNA isoforms. At present, the most complex alterations in 5-HT2C pre-mRNA editing were found in brains of depressed suicide victims. In these brains, 5-HT2C receptor isoforms with reduced function are expressed at significantly increased levels, suggesting that the regulation of editing by synaptic serotonin is defective.

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