Identification and Immunotherapeutic Targeting of Antigens Induced by Chemotherapy  

Oleh:

Rubinfeld, Bonnee ; Upadhyay, Archana ; Clark, Suzanna L. ; Fong, Sharon E. ; Smith, Victoria ; Koeppen, Hartmut ; Ross, Sarajane ; Polakis, Paul

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Biotechnology: The Science and Business of Biotechnology vol. 24 no. 2 (Feb. 2006), page 205-209.
Topik: chemotherapy; immunotherapeutic; antigen; chemotherapy

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: NN9.4 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Cancer cells differ from normal cells in their response to chemotherapy. We exploited this dissimilarity by identifying and targeting tumor specific, cell surface proteins whose expression is induced by the chemotherapeutic irinotecan (CPT-11; Camptosar). A cytotoxin armed antibody reactive with one of these drug induced surface proteins, the LYGD / E48 antigen, originally identified as the target of a monoclonal antibody reactive with squamous cell carcinomas, caused complete regression of colorectal tumor xenografts in mice treated with CPT-11, whereas either agent alone was less effective. These results suggest that a positive therapeutic index may be generated for other drug combinations by immunotherapeutic targeting of chemotherapy induced antigens.

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