AAV Does The Shuffle  

Oleh:

Asokan, Aravind ; Samulski, R. Jude

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Biotechnology: The Science and Business of Biotechnology vol. 24 no. 2 (Feb. 2006), page 158-159.
Topik: viruses; AAV; shuffle

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: NN9.4 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Directed evolution of adeno associated virus (AAV) yields mutant vectors that can evade neutralizing antibodies. DNA shuffling and related recombination techniques can dramatically accelerate the evolution of geentic mutations and enhance phenotypic traits. Such technology has been exploited to evolve proteins with improved stability and processing yield, enzymes with novel catalytic features, vaccines with increased immunogenicity and hybrid retroviruses...

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