Transient Inhibition of BMP Signaling by Noggin Induces Cardiomyocyte Differentiation of Mouse Embryonic Stem Cells  

Oleh:

Shimazaki, Toson ; Yuasa, Shinsuke ; Itabashi, Yuji ; Koshimizu, Uichi ; Tanaka, Tomofumi ; Sugimura, Keijiro ; Kinoshita, Masayoshi ; Hattori, Fumiyuki ; Fukami, Shin-ichi ; Okano, Hideyuki ; Ogawa, Satoshi ; Fukuda, Keiichi

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Biotechnology: The Science and Business of Biotechnology vol. 23 no. 5 (Mei 2005), page 607-611.
Topik: STEM CELL; BMP. noggin induce; embryonic stem cells

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: NN9.3 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Embryonic stem (ES) cells are a promising source of cardiomyocytes, but clinical application of ES cells has been hindered by the lack of reliable selective differentiation methods. Differentiation into any linkeage is partly dependent on the regulatory mechanisms of normal early development. Although several signals, including bone morphogenetic protein (BMP), Wnt, and FGF are involved in heart development, scare evidence is available about the exact signals that mediate cardiomyocyte differentiation. While investigating the involvement of BMP signaling in early heart formation in the mouse, we found that the BMP antagonist noggin is transiently but strongly expressed in the heart forming region during gastrulation and acts at the level of induction of mesendoderm to establish conditions condusive to cardiogenesis. We applied this finding to develop an effective protocol for obtaining cardiomycocytes from mouse ES cells by inhibition of BMP signaling.

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