Baculovirus as Versatile Vectors for Protein Expression in Insect and Mamalian Cells  

Oleh:

Kost, Thomas A. ; Condreay, J. Patrick ; Jarvis, Donald L.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Biotechnology: The Science and Business of Biotechnology vol. 23 no. 5 (Mei 2005), page 567-576.
Topik: PROTEIN; protein; mammalian cells

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: NN9.3 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Today, many thousands of recombinant proteins, ranging from cytosolic enzymes to membrane bound proteins, have been successfully produced in baculovirus in fected insect cells. Yet, in addition to its value in producing recombinant proteins in insect cells and larvae, this viral vector system continues to evolve in new and unexpected ways. This is exemplified by the development of engineered insect cell lines to mimic mammalian cell glycoylation of expressed proteins, baculovirus display strategies and the application of the virus as a mammalian-cell gene delivery vector. Novel vector design and cell engineering approaches will serve to further enhance that value of baculovirus technology.

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