Integrative Model of The Response of Yeast to Osmotic Shock  

Oleh:

Klipp, Edda ; Nordlander, Bodil ; Kruger, Roland ; Gennemark, Peter ; Hohmann, Stefan

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Biotechnology: The Science and Business of Biotechnology vol. 23 no. 8 (Agu. 2005), page 975-982.
Topik: MODEL; integrative model; yeast to osmotic shock

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: NN9.4 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Integration of experimental studies with mathematical modelling allows insight into systems properties, prediction of peturbation effects and generation of hypotheses for further research. We present a comprehensive mathematical description of the cellular response of yeast to hyperosmotic shock. The model integrates a biochemical interaction network comprising receptor stimulation, mitogen-activated protein kinase cascade dynamics, activation of gene expression and adaptation of cellular metabolism with a thermodynamic description of volume regulation and osmotic pressure. Simulations agree well with experimental results obtained under different stress conditions or with specific mutants. The model is predictive since it suggests previously inrecognized features of the system with respect to osmolyte accumulation and feedback control, as confirmed with experiments. The mathematical description represented is a valuable tool for future studies on osmoregulation in yeast and with appropriate modifications other organisms. It also serves as a starting point for a comprehensive description of cellular signaling.

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