siRNA Becomes Smart and Intelligent  

Oleh:

Miyagishi, Makoto ; Taira, Kazunari

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Biotechnology: The Science and Business of Biotechnology vol. 23 no. 8 (Agu. 2005), page 946-948.
Topik: rna; RNA; smart and intelligent

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: NN9.4 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Designing small interfering RNAs is facilitted by an artificial neural networks algorithm. In just a few years, small interfering RNA (siRNA) has emerged as a powerful technology to specifically knockdown genes in mamalian cells both for functional analysis and for therapeutic purposes. The success of this approach, also called RNA interference (RNAi), hinges on the affinity of an siRNA molecule for its target mRNA. Many different algorithm for designing siRNAs have been developed, but they remain of limited utility. In this issue, Hall et al, report the first artificial neural network (ANN) - based algorithm for designing siRNAs and used it to generate a library of siRNA for more than 24,000 human genome...

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