Magnetic Resonance Tracking of Dendritic Cells in Melanoma Patients for Monitoring of Cellular Therapy  

Oleh:

Vries, I. Jolanda M. de ; Lesterhuis, W. Joost ; Barentsz, Jelle O. ; Verdijk, Pauline ; Krieken, J. Han van ; Boerman, Otto C. ; Oyen, Wim J.G. ; Bonenkamp, Johannes J. ; Boezeman, Jan B. ; Adema, Gosse J. ; Bulte, Jeff W. M. ; Scheenen, Tom W. J. ; Punt, Cornelis J.A. ; Heerschap, Arend ; Figlor, Carl G.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Biotechnology: The Science and Business of Biotechnology vol. 23 no. 11 (Nov. 2005), page 1407-1413.
Topik: CELLULAR; magnetic resonance; dendritic cells; melanoma patient; cellular therapy

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: NN9.4 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

The success of cellular therapies will depend in part on accurate delivery of cells to target organs. In dendritic cell therapy, in particular, delivery and subsequent migration of cells to regional lymph nodes is essential for effective simulation of the immune system. We show here that in vivo magnetic resonance tracking of magnetically labeled cells in feasible in humans for detecting very low numbers of dendritic cells in conjunction with detailed anatomical information. Autologous dendritic cells were labeled with a clinical super paramagnetic iron oxide formulation or in-oxine and were co-injected intranodally in melanoma patients under ultrasound guidance. In contrast to scientigraphic imaging, magnetic resonance imaging (MRI) allowed assessment of the accuracy of dendritic cell delivery and or inter and intra noda cell migration patterns. MRI cell tracking using iron oxides appears clinically safe and well suited too monitor cellular therapy in humans.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali