Activation of The Mamalian Immune System by siRNAs  

Oleh:

Williams, Bryan R.G. ; Marques, Joao T.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Biotechnology: The Science and Business of Biotechnology vol. 23 no. 11 (Nov. 2005), page 1399-1406.
Topik: IMMUNE SYSTEM; activation; mammalian immune; RNA

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: NN9.4 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Inhibition of gene expression through RNA interference (RNAi) is emerging as a powerful experimental tool for gene functon and target validation studies. The potential uses of this technology seem unlimited, extending to the prevention and therapy of human diseases. However, recent work demonstrating that there are unanticipated, different nonspecific effects associated with the use of small interfering RNAs in mammals has raised concerns about the safe use of RNAi in vivo. These nonspecific effects include activation of the immune system, potentially harming the individual. The application of screening assays for nonspecific activation of both innate and acquired immunity will be necessary for further development of RNAi as a therapeutic tool.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali