Synthetic Biomaterials as Instructive Extracellular Microenvironments for Morphogenesis in Tissue Engineering  

Oleh:

Lutolf, M.P. ; Hubbell, J. A.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Biotechnology: The Science and Business of Biotechnology vol. 23 no. 1 (Jan. 2005), page 47-56.
Topik: MATERIALS; synthetic biomaterials. extracellular microenvironments; tissue engineering

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: NN9.2 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

New generations of synthetic biomaterials are being developed at a rapid pace for use as three dimensional extracellular micro environments to mimic the regulatory characteristics of natural extracellular matrice (ECMs) and ECM bound growth factors, both for theurapeutic applications and basic biological studies. Recent advances include nano fibrillar networks formed by self assembly of small buiding blocks, artificial ECM networks form protein polymers or peptide conjugated synthetic polymers that present bioactive ligands and respond to cell secreted signals to enable proteolytic remodeling. These materials have already found application in differentiating stem cells into neurons, repairing bone and inducing angiogenesis. Although modern synthetic biomaterials represent over simplified mimics of natural ECMs lacking the essential natural temporal and spatial complexity, a growing symbiosis of material engineering and cell biology may ultimately result in synthetic materials that contain the necessary signals to recapitulate developmental processes in tissue and organ specific differentiation and morphogenesis.

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