Thiol Modifications in a Snapshot  

Oleh:

Bardwell, James

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Biotechnology: The Science and Business of Biotechnology vol. 23 no. 1 (Jan. 2005), page 42-44.
Topik: oxidation; thiol modification; snapshot

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: NN9.2 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The oxidation state of proteins in cells can be analyzed with a simple labeling methods. Taking a picture of the oxidation state of proteins in vivo involves substantial technical challemges that are similar to what photographers call the red eye problem. Just as it is difficult to photograph someone without distorting their image as seen in eyes glowing red from the light of a flash sample processing can easily cause artifactual oxidation or reduction of proteins in cells. Moreover, modifying a protein with a thiol specific probe changes its behaviour, complicating the task of determining what fraction of a given protein is modified...

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