Preservering The Genetic Integrity of Human Embryonic Stem Cells  

Oleh:

Mitalipova, Maisam M. ; Rao, Raj R. ; Hoyer, Deborah M. ; Johnson, Julie A. ; Meisner, Lorraine F. ; Jones, Karen L. ; Dalton, Stephen ; Stice, Steven L.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Biotechnology: The Science and Business of Biotechnology vol. 23 no. 1 (Jan. 2005), page 19-20.
Topik: STEM CELL; genetic; human embryonic; stem cell

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: NN9.2 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The limited number of human embryonic stem (hES) cell lines heightens the need to maintain their genetic integrity. A report by draper et al published in last january's issue (nat biotechnol 22, 53-54, 2004) and a related correspondence from buzzard and colleagues in the April issue (nat biotechnol 22, 381-382) suggest that hES cell lines propagated in vitro for even a few months can sevelop an abnormal karyotype. We report here data from our laboratory that throw more light on the genetic stability of hES cell lines and its relation to how cells are maintained in culture...

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