A New School for Screening  

Oleh:

Jhoti, Harren

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Biotechnology: The Science and Business of Biotechnology vol. 23 no. 2 (Feb. 2005), page 184-185.
Topik: SCREENING; new school; screening

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: NN9.2 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Fragment based methods for identifying lead compounds are a promising alternative to traditional drug discovery approaches. As the pharmaceutical industry continues to struggle to improve productivity, many are questioning all aspects of the drug discovery process. One issue, perhaps the heart of the problem, is that of efficiently discovering high quality drug leads. In this issue, card et al. Introduce a fragment based discovery method, which they refer to as scaffold based drug design and demonstrate its utility in the rapid identification of cyclic nucleotide phosphodiesterase (PDE) inhibitors. Over the last decade, the area of small molecule lead discovery has witnessed the impact of several new technologies and approaches, including combinatorial chemistry, paralel chemical synthesis and high throughput screening (HTS)...

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