New Source of Pancreatic B-cells  

Oleh:

Weir, Gordon C. ; Booner-Weir, Susan

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Biotechnology: The Science and Business of Biotechnology vol. 23 no. 7 (Jul. 2005), page 857-861.
Topik: sources; sources; pancreatic b-cells

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: NN9.3 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Two major initiatives are under way to correct the b-cell deficit of diabetes, one would generate b-cells ex vivo that are suitable for transplantation, and the second would stimulate regeneration of b-cells in the pancreas. Studies or ex vivo expansion suggest that b-cells have a potential for dedifferentiation, expansion and redifferentiation. Work with mouse and human embryonic stem (ES) cells has not yet produced cells with the pehontype of true b-cells, but there has been recent progress in directing ES cells to endoderm. Putative islet stem progenitor cells have been identified in mouse pancreas and formation of new b-cells from duct, acinar and liver cells in an active area of investigation. Peptides, including glucagon like peptide 1 / exedine 4 and the combination of epidermal growth factor and gastrin, can stimulate regeneration of b-cells in vivo. Recent progress in the search for new sources of b-cells has opened promising new opportunities and spawned clinical trials.

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