Where did The BLOSUM62 Alignment Score Matrix Come From ?  

Oleh:

Eddy, Sean R.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Biotechnology: The Science and Business of Biotechnology vol. 22 no. 8 (Agu. 2004), page 1035-1036.
Topik: matrix; BLOSUM62; alignment score matrix

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: NN9.1 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Many sequence alignment programs use the BLOSUM62 score matrix to score pairs of aligned residues. Where did BLOSUM62 come from? Back in the good old days, so many things were easier to understand. I once disassembled the engine of my 1972 MG just to see how it worked, but ow I won't touch the squirrel's nest of technology that's inside my modern Honda Civic. likewise in the early days of sequence comparison, alignment scores were straightforward stuff that anybody could tweak. The first sequence comparisons just assigned -1 per mismatch and -1 per insertion / deletion, and if you didn't like that, you could make up whatever scores you thought gave you better looking alignments...

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