In Vivo Cancer Targeting and Imaging With Semiconductor Quantum Dots  

Oleh:

Xiaohu, Gao ; Yuanyuan, Cui ; Levenson, Richard M. ; Chung, Leland W. K. ; Shuming, Nie

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Biotechnology: The Science and Business of Biotechnology vol. 22 no. 8 (Agu. 2004), page 969-976.
Topik: QUANTUM THEORY; in vivo cancer; semiconductor quantum dots

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: NN9.1 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

We describe the development of multifunctional nanoparticle probes based on semiconductor quantum dots (QDs) for cancer targeting and imaging in living animals. The structural design involves encapsulating luminescent QDs with an ABC triblock copolymer and linking this amphiphilic polymer to tumor targeting ligands and drug delivery functionalities. In vivo targeting studies of human prostate cancer growing in nude mice indicate that the QD probes accumulate at tumors both by the enhanced permeability and prostate cancer growing in nude mice indicate that the QS probes accumulate at tumors both by the enhanced permeability and retention of tumor sites and by antibody binding to cancer specific cell surface biomakers. Using both subcutaneous injection of multifunctional QD probes, we have achived sensitive and multicolor fluorescence imagig of cancer cells under in vivo conditions. We have also integrated a whole body macro illumination system will wavelength resolved spectral imaging for efficient background removal and precise delineation of weak spectral signatures. These results raise new possibilities for ultrasensitive and multiplexed imaging of molecular targets in vivo.

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