A Common Open Representation of Mass Spectrometry Data and Its Application to Proteomics Research  

Oleh:

Smith, Richard ; Pratt, Brian ; Pedrioli, Patrick G.A. ; Eng, Jimmy K. ; Hubley, Robert ; Vogelzang, Mathijs ; Deutsch, Eric W. ; Raught, Brian ; Nilsson, Erik ; Angeletti, Ruth H. ; Apweiler, Rolf ; Kei Cheung ; Costello, Catherine E. ; Hermjakob, Henning ; Huang, Sequin ; Julian, Randall K. ; Kapp, Eugene ; McComb, Mark E. ; Oliver, Stephen G. ; Omenn, Gilbert ; Paton, Norman W. ; Simpson, Richard ; Taylor, Chris F. ; Weimin, Zhu ; Aebersold, Ruedi

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Nature Biotechnology: The Science and Business of Biotechnology vol. 22 no. 11 (Nov. 2004), page 1459-1466.
Topik: RESEARCH; common open representatin; mass spectrometry data; proteomics research

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: NN9.3 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

A broad range of mass spectrometers are used in mass spectrometry (MS) based proteomics research. Each type of instrument possesses a unique design, data system and performance specifications, resulting in strengths and weaknesses for different types of experiments. Unfortunately the native binary data formats produced by each type of mass spectometer also differ and are usually proprietary. The diverse, nontransparent nature of the data structure complicates the intergration of new instruments into preexisting infrastructure, impedes the analysis, exchange, comparison and publication of results from different experiments and laboratories and prevents the bioinformatics community from accessing data sets required for software development. Here, we introduce the mzXML format, an open, generic XML (extensible markup languange) representation of MS data. We have also developed an accompanying suite of supporting programs. We expect that this format will facilitate data management, interpretation and dissemination in proteomics research.

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