Penetapan nilai parameter lipofilisitas (Log P, jumlah tetapan p Hansch dan tetapan f Rekker) asam pipemidat  

Oleh:

Aryani, Ni Luh Dewi

Jenis: Article from Journal - ilmiah nasional
Dalam koleksi: Jurnal Ilmiah Sains dan Teknologi vol. 01 no. 02 (Feb. 2006), page 93-100.
Topik: f REKKER; p HANSCH; LOG P; PIPEMIDIC ACID

Ketersediaan

Perpustakaan PKPM Nomor Panggil: J110 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Lipophilicity is the most often used physicochemical property in quantitative structure activity relationship (QSAR) studies because it is related to the absorption across biological membrane and the distribution between body fluid and lipid rich phase of drugs. Its quantitative descriptor is the octanol water partition coefficient (usually expressed as log P). The values of logarithmic intrinsic partition coefficient (IPC) and apparent partition coefficient (APC) of pipemidic acid were -2,03 +/- 0,25 and -3,932 +/- 0,25. The values of logarithmic partition coefficient, which were obtained by calculating of p Hansch and f Rekker constant were -1,65 and -1,981, respectively.

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