Pengaruh Perlindungan Ekstrak Rimpang Bangle (Zin Giber Cassumunar Roxb) Terhadap Kerusakan Hail Tikus Yang Diinduksi CCI4  

Oleh:

Wresdiyati, Tutik ; Muchtadi, Deddy ; Zakaria, Fransiska R. ; Sidik ; Arafah, Elmeizy

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Jurnal Teknologi dan Industri Pangan vol. XV (2004), page 214-220.
Topik: Liver Damage; Hepatoprotector; Zingiber Cassumunar

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: TT33 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Zingiber cassumunar Roxb known as Bangle, has antioxidative and antiinflammatory activities. It has been used for medicinal purposes traditionally. The aim of this study was to investigate whether administration of Z. cassumunar extracts orally may prevent acute liver damage induced by carbontetrachloride (CCI4) in rats. The study was carried out on 5 groups of male Sprague-Dawley rats (n=5). Group I was given ethyl acetate fraction of Bangle rhizome extract (30 mg/kg bw) (KS), group 2 was given dry juice of Bangle rhizome (30 mg/kg bw) (SK), group 3 was given curcuminoid (30 mg/kg bw) (KUR), group 4 as negative control (KN) given 5% Tween 80 solution (10 mI/kg bw) and Group 5 as control (K). Carbontetrachloride 0,1 mI/kg bw was given orally after 7 days to group KS, 5K, KUR and KN. Rats were terminated 24 hours after CCI4-induction. Liver injury was evaluated by analyzed SGPT and SGOT activities from the serum and histopathologycal examination was conducted on the liver, The results clearly indicated that extracts of Z cassumunar could reduced significantly the degree of liver damage induced by CCI4. It may be concluded that Z. cassumunar rhizome could be used as substance for hepatoprotector.

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