Antisocial Peer Affiliation and Externalizing Disorders: Evidence for Gene × Environment × Development Interaction  

Oleh:

Samek, Diana R. ; Hicks, Brian M. ; Keyes, Margaret A. ; Iacono, William G. ; McGue, Matt

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Development and Psychopathology vol. 29 no. 1 (Feb. 2017), page 155-172.
Topik: childhood ; adolescence; adolescence for antisocial behavior; adulthood; childhood and adolescence

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: DD21 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Gene × Environment interaction contributes to externalizing disorders in childhood and adolescence, but little is known about whether such effects are long lasting or present in adulthood. We examined gene–environment interplay in the concurrent and prospective associations between antisocial peer affiliation and externalizing disorders (antisocial behavior and substance use disorders) at ages 17, 20, 24, and 29. The sample included 1,382 same-sex twin pairs participating in the Minnesota Twin Family Study. We detected a Gene × Environment interaction at age 17, such that additive genetic influences on antisocial behavior and substance use disorders were greater in the context of greater antisocial peer affiliation. This Gene × Environment interaction was not present for antisocial behavior symptoms after age 17, but it was for substance use disorder symptoms through age 29 (though effect sizes were largest at age 17). The results suggest adolescence is a critical period for the development of externalizing disorders wherein exposure to greater environmental adversity is associated with a greater expression of genetic risk. This form of Gene × Environment interaction may persist through young adulthood for substance use disorders, but it appears to be limited to adolescence for antisocial behavior.

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