Diagnostic Test on the Fourth Generation Human Immunodeficiency Virus in HIV Suspects  

Oleh:

Sofitri ; Nasrul, Ellyza ; Almurdi ; Efrida

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Clinical Pathology and Medical Laboratory vol. 23 no. 02 (Mar. 2017), page 172-177.
Topik: Diagnostic Test; Fourth-Generation HIV Test; HIV RNA
Fulltext: I01 v23 n2 p172 kelik2017.pdf (490.64KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: I01.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Early diagnosis for Human Immunodeficiency Virus (HIV) infection can reduce the risk of transmission. Acute infection diagnosis based on antigen assay or ribonucleic acid test (RNA/proviral DNA). Enzyme Immunoassay (EIA) fourth generation can detect HIV p24 antigen and antibodies simultaneously. The research objective was to determine the diagnostic value of the fourth-generation HIV testing in HIV suspects. This was a diagnostic test with cross-sectional design, perfomed on 70 patients with suspected HIV who came to the Volunters Counselling and Testing clinic (VCT) Dr. M. Djamil Hospital Padang from Maret 2015 to Maret 2016. The study was aimed to measure the diagnostic values (sensitivity, specificity, positive predictive value, negative predictive value) of fourth generation HIV tests with Enzyme Linked Fluorescent Assay (ELFA) against Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) RNA HIV and analyzed using crosstab 2×2. The were 70 subjects, consisting of 46 males (65.7%) and 24 females (34.3%) with a diagnosis of HIV suspects. Mean of age was 27.7 year. Heterosexual was the major transmision of HIV. The sensitivity and specificity of fourth-generation HIV test against HIV RNA were 95% and 96% respectively, and the positive predictive value and negative predictive value were 97 and 92%, respectively.

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