Correlation of Coagulation Status and Ankle Brachial Index (ABI) in Diabetes Mellitus Patients with Peripheral Arterial Disease  

Oleh:

Hutagalung, Lany Anggreani ; Aman, Adi Koesema ; Syafril, Syanti

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Clinical Pathology and Medical Laboratory vol. 23 no. 02 (Mar. 2017), page 157-161.
Topik: Diabetes Mellitus; Peripheral Arterial Disease; Coagulation Status; Ankle Brachial Index
Fulltext: I01 v23 n2 p157 kelik2017.pdf (409.8KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: I01.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Diabetes Mellitus (DM) is commonly associated with both microvascular and macrovascular complications. Hyperglycemia, a well-defined risk factor for accelerated atherosclerosis and vascular disease, may cause vessel damage and resulting in glycation of hemoglobin, prothrombin, fibrinogen and other proteins involved in clotting mechanisms. The glycation results in the incomplete activation and function of the clotting cascade. Diabetes mellitus is a risk factor for Peripheral Arterial Disease (PAD). This research is aimed to know the correlation between coagulation status, Ankle Brachial Index (ABI) and PAD in patients with DM. This study was an observational analytical study that was performed in the Adam Malik Hospital Medan, from April to October 2015. All samples were examined for Ankle Brachial index (ABI) and coagulation parameters such as PT, APTT, fibrinogen and D-dimer level. There was a significantly difference between fibrinogen and D-dimer level with PAD. DM patients with PAD had significantly higher fibrinogen and D-dimer levels compared with DM patients without PAD (333.35±127.49 vs 244.95±83.96; p=0.001) and (648.40±443.96 vs 302.45±108.41; p=0.008). There was a significantly difference between fibrinogen and D-dimer level with severity of PAD, whereas severe PAD had significantly higher fibrinogen and D-dimer levels compared with mild PAD (374.00±114.94 vs 327.14±136.45; p=0.012) and (1170.67±398.72 vs 537.36±348.08; p=0.012). Also there was a negative correlation between D-dimer level and ABI values (r -0.577; p=0.000). Diabetes mellitus patients with PAD had significantly higher fibrinogen and D-dimer levels compared with DM patients without PAD. There was a negative correlation between D-dimer level and ABI values.

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