Correlation of Antinuclear Antibody (ANA) Profile with Hematologic and Renal Disorders in Systemic Lupus Erythematosus  

Oleh:

Wijaya, Chelvi ; Nurulita, Asvin ; Bahrun, Uleng

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Clinical Pathology and Medical Laboratory vol. 23 no. 02 (Mar. 2017), page 146-151.
Topik: Systemic Lupus Erythematosus; ANA Profile; Autoimmune; Autoantibody
Fulltext: I01 v23 n2 p146 kelik2017.pdf (326.32KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: I01.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Systemic Lupus Erythematosus (SLE) is an autoimmune disease which affects multiple organs. Hematologic manifestation is common, as well as renal involvement, one of the very influential factors in SLE. Anti-Nuclear Antibody (ANA) Profile test can detect spesific antinuclear antibodies. These autoantibodies are supposedly associated with the clinical manifestation. A retrospective analytical study was done in the Clinical Pathology Laboratory and Medical Record Installation of Dr. Wahidin Sudirohusodo Hospital Makassar by collecting the result of ANA profile, complete blood count and urinalysis test from suspected SLE patients during the period of January 2014–July 2016. Data were grouped into SLE and non-SLE. Statistical analysis was done by Chi Square and Fisher test. 72 samples were collected, 39 of them were SLE. There was a significant association between anti RNP/Sm, Sm, SS-A, Ro-52, dsDNA, Nucleosome, Histones, Ribosomal P with SLE (p<0.05). There was a significant association between anti-dsDNA (p=0.029) and anti-nucleosome (p=0.037) with anemia and anti-dsDNA (p=0.013) and anti-nucleosome (p=0.036) with renal involvement. There was no significant association between autoantibodies in this study with leukopenia, lymphopenia and trombositopenia. Anti-RNP/Sm, Sm, SS-A, Ro-52, dsDNA, nucleosome, histones, Ribosomal P are associated with SLE. Anti-dsDNA and anti-nucleosome were associated with anemia and renal manifestation in SLE, so they may be used to predict this events, although further study is needed to prove it. There was no autoantibody that can be associated with leukopenia, lymphopenia and thrombositopenia.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali