Correlation between Serum Tissue Polypeptide Specific Antigen Level and Prostate Volume in BPH  

Oleh:

Bumbungan, Mahrany Graciella ; Retnowati, Endang ; Djatisoesanto, Wahjoe

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Clinical Pathology and Medical Laboratory vol. 23 no. 02 (Mar. 2017), page 141-145.
Topik: BPH; Tissue Polypeptide Specific Antigen; Prostate Volume
Fulltext: I01 v23 n2 p141 kelik2017.pdf (486.78KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: I01.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Prostate volume has become an important information because it can predict morbidity in Benign Prostatic Hyperplasia (BPH). Prostate volume is measured using TRUS (transrectal ultrasonography) as a gold standard; but this has some disadvantages. Other parameters are needed to predict prostate volume. Tissue Polypeptide Specific Antigen (TPS) detected in the circulation consists of cytokeratin fragments contained in the tissue and show the proliferation status. Benign Prostatic Hyperplasia epithelial cells containing cytokeratin 18 will undergo hyperplasia, so it can be detected by TPS examination. The aim of this study was to prove any correlation between the levels of serum TPS and prostate volume. Study subjects consisted of 28 BPH patients from the Urology Outpatient Clinic Dr. Soetomo Hospital Surabaya. Prostate volume was measured using TRUS. Levels of serum TPS were measured using ELISA method (TPS® ELISA IDL Biotech). Levels of serum TPS ranged between 82.45–1771.5 U/L (195.35±349.79 U/L). Prostate volume varied between 20.7-87.4 cm (34.70±15.31 cm). No significant positive correlations between levels of serum TPS and prostate volume were found (p=0.404; r=0.164).

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