Correlation Between NT-proBNP and Left Ventricular Ejection Fraction by Echocardiography in Heart Failure Patients  

Oleh:

Mutiara D. S. ; Anniwati, Leonita ; Aminuddin, M.

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Clinical Pathology and Medical Laboratory vol. 23 no. 02 (Mar. 2017), page 114-118.
Topik: NT-proBNP; Left Ventricular Ejection Fraction (LVEF); Heart Failure; Fraksi Ejeksi Ventrikel Kiri; Gagal Jantung
Fulltext: I01 v23 n2 p114 kelik2017.pdf (557.85KB)

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Perpustakaan FK Nomor Panggil: I01.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Biological marker NH2-terminal fragment of pro-Brain Natriuretic Peptide (NT-proBNP) is useful for early diagnosis, to role out the clinical symptoms originating from outside the heart, monitoring treatment and predicting prognosis in heart failure patients. NT-proBNP eaxamination can be done automatically, so the results are not subjective. Echocardiography is the examination commonly used to help diagnosing heart failure. However, echocardiography is not always available in all hospitals, especially small hospitals in the rural areas and requires expertise in conducting examination and the results are subjective. One of the parameters assessed by echocardiography is the left ventricular ejection fraction (LVEF). The study design was quasi-experimental with pre-test and post-test approach only without control. Samples consisted of 41 subjects collected from February to April 2015 from the Cardiology Unit, Dr. Soetomo Hospital, Surabaya. NT-pro BNP was examined using a solid-phase two-site chemiluminescent immunometric assay as the principle. The results were statistically analyzed using Spearman’s correlation test, two sample paired test, Kruskal Wallis and Mann Whitney test. NT-proBNP levels before and after therapy in heart failure patients were each between 1,296–3,474 pg/mL, mean 10,422.49 pg /mL (SD 8,608.05) and 997–3,401 pg/mL, mean 8,899.41 pg/mL (SD 8,489.46). The range of the percentage of LVEF before and after therapy in heart failure patients was etween 20–62%, mean 35.61% (SD 10.00) and 22–71%, mean 41.49% (SD 10.96). Significant differences in mean levels of NT-proBNP and LVEF before and after therapy in heart failure patients with each value of p=0.001 were found. A significant negative correlation between levels of NT-proBNP with LVEF in heart failure patients before and after therapy with the values of p=0.001, r=-0.81 and p=0.001, r=-0. 80, respectively was also shown. A significant negative correlation between the levels of NT-proBNP with LVEF in heart failure patients before and after therapy was found. Based on these conditions, examination of biological markers NT-proBNP can be suggested to be used as an alternative to echocardiography parameters for heart failure.

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