Monocyte Lymphocyte Ratio in Dengue Hemorrhagic Fever  

Oleh:

Retnoningrum, Dwi ; Purwanto A. P.

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Clinical Pathology and Medical Laboratory vol. 23 no. 02 (Mar. 2017), page 111-113.
Topik: Dengue Hemorrhagic Fever; Monocyte Lymphocyte Ratio; DHF Degree; Derajat DHF
Fulltext: I01 v23 n2 p111 kelik2017.pdf (267.86KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: I01.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Dengue Hemorrhagic Fever (DHF) is a disease caused by dengue virus transmitted through mosquito bites. Dengue hemorrhagic fever causes high morbidity and mortality in the world, including Asia, especialy in Indonesia. The pathogenesis of DHF infection is thought to involve monocytes and lymphocytes as a result of the immune response to infection. Monocyte Lymphocyte Ratio (MLR) previously used in describing the immune response to malaria infection, tuberculosis and HIV. To determine whether there are differences between MLR in mild and severe DHF. A cross-sectional study in DHF patients at the Dr. Kariadi Hospital Semarang was done in January to December 2013. Monocyte lymphocyte ratio value was obtained from calculating the number of monocytes divided by lymphocytes from leukocyte differential count. The degree of DHF was determined in accordance to the WHO criteria, where grade I-II was considered as a mild degree and grade III-IV was considered as severe degree. Statistical analysis analyzed by Student’s t test. Group I consisted of 40 patients with mild DHF and group II consisted of 40 patients with severe DHF. The subjects consisted of 41 males (51.2%) and 39 females (48.8%). Monocyte lymphocyte ratio value range in mild DHF was from 0.03 to 0.33 (median 0.11), while the severe DHF from 0.03 to 0.59 (median 0.16). Statistical analysis showed there was no significant difference between the value of MLR group I (mild) and group II (severe) (p=0.08). There was no significant difference of MLR in mild and severe DHF.

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