The Correlation of Naive CD4+T Lymphocyte Cell Percentage, Interleukin-4 Levels and Total Immunoglobulin E in Patients with Allergic Asthma  

Oleh:

Si Ngr ; Putrawan, Oka ; Retnowati, Endang ; Maranatha, Daniel

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Indonesian Journal of Clinical Pathology and Medical Laboratory vol. 23 no. 01 (Nov. 2016), page 84-89.
Topik: Naive CD4+ T Lymphocytes; IL-4; Total IgE; Allergic Asthma Patients
Fulltext: I01 v23 n1 p84 kelik2017.pdf (370.96KB)

Ketersediaan

Perpustakaan FK Nomor Panggil: I01.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Allergic asthma is the most common asthma phenotype found in children and adults. Allergen will enter the respiratory tract and trigger an immune response, causing asthma symptoms. The aim this study was to prove the existence of a correlation between the percentage of naive CD4+ T cell lymphocytes with levels of IL-4 and the amount of total IgE in patients with allergic asthma. This was analytic observational study with cross sectional design. Samples consisted of 25 patients with allergi asthma. Examination of the percentage of naive CD4+ T cell lymphocytes was done by flowcytometry, levels of IL??4 was determined by Enzyme Linked Immunosorbent Assay (ELISA) and amount of total IgE was by chemiluminescence. The percentage of naive CD4+ T cell lymphocytes was likely to increase in the range of 25.74 to 47.68% with a mean of 36.72% and a standard deviation (SD) of 6.0%. Levels of IL-4 ranged from 43.4 to 97.2 pg/mL with a mean of 70.8 pg/mL and SD of 14,9 pg/mL. The amount of total IgE also increase and ranged from 231.8 to 684.8 IU/mL with a mean of 410.9 IU/mL and SD of 114.6 IU/mL. There was a correlation between the percentage of naive CD4+ T cell lymphocytes with levels of IL-4 and the amount of total IgE in patients with allergic asthma.

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